John Wesley on 2 Thessalonians 2:3

Henricus 4. Emperour surrendering his crowne to the Pope. Image of Antichrist

“However, in many respects, the Pope has an indisputable claim to those titles. He is, in an emphatical sense, the man of sin, as he increases all manner of sin above measure. And he is, too, properly styled, the son of perdition, as he has caused the death of numberless multitudes, both of his opposers and followers, destroyed innumerable souls, and will himself perish everlastingly. He it is that opposeth himself to the emperor, once his rightful sovereign; and that exalteth himself above all that is called God, or that is worshipped. Commanding angels and putting kings under his feet, both of whom are called gods in scripture; claiming the highest power, the highest honour; suffering himself, not once only, to be styled God or vice-God. Indeed no less is implied in his ordinary title, ‘Most Holy Lord,’ or ‘Most Holy Father,’ so that he sitteth enthroned in the temple of God, mentioned in Rev. 11:1. Declaring himself that he is God – claiming the prerogatives which belong to God alone.””

Source and read more: https://xmassh8trsblog.wordpress.com/2016/07/01/who-is-this-man-of-sin-the-son-of-perdition/